美国的高露洁应该是最早开卖牙膏的公司，而中国1926年在上海生产了第一支牙膏，名为三星牌。
牙膏的包装基本上没有什么变化，如果说有变化，也是大同小异。今天这个牙膏的包装，是将纸盒包装和软管一体的设计，去掉纸盒包装减少成本，这种外形设计可以增加运输的空间，而且更容易挤压，减少牙膏的残留，避免浪费。设计：Sang Min Yu and Wong Sang Lee。
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